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HRID389597

反应详情

EQUATION

反应方程式

HRID 389597 的结构方程式

REACTANTS

反应物

2
结构：Fc1cccc(-c2cc(Br)c3snnc3c2)c1
HCID66760139

未命名化合物

结构：CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(-c2cnn([C@H]3CC[C@H](O[Si](C)(C)C(C)(C)C)CC3)c2)c2cc(B(O)O)oc12
HCID178454343

未命名化合物

PRODUCTS

生成物

1
结构：Nc1ncc(-c2cnn([C@H]3CC[C@H](O)CC3)c2)c2cc(-c3cc(-c4cccc(F)c4)cc4nnsc34)oc12
HCID178508365

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from {7-[bis(tert-butoxycarbonyl)amino]-4-[1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-2-yl}boronic acid and 7-bromo-5-(3-fluorophenyl)-1,2,3-benzothiadiazole by a procedure analogous to Example 368. 1H NMR (400 MHz, CD3OD): δ 1.48-1.57 (m, 2 H), 1.94-2.05 (m, 2 H), 2.11-2.22 (m, 4 H), 3.67-3.75 (m, 1 H), 4.21-4.29 (m, 1 H), 7.19-7.26 (m, 1 H), 7.53-7.63 (m, 2 H), 7.72-7.77 (m, 2 H), 7.89 (s, 2 H), 8.08 (s, 1 H), 8.70 (s, 1 H), 8.90 (s, 1 H); MS (ESI): 527.60 [M+H]+; HPLC tR=1.07 min (TOF: polar—2 min).

WORKUP

后处理

  1. customHPLC tR=1.07 min (TOF: polar—2 min)