Dimethylamine → HCID 66760220, compound

HRID 389600Notes

Reaction equation

HRID 389600 reaction equation
[Br:1][C:2]1[C:10]2[S:9][C:8](Cl)=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:12][NH:13][CH3:14]>>[Br:1][C:2]1[C:10]2[S:9][C:8]([N:13]([CH3:14])[CH3:12])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 667605757-BroMo-2-chlorobenzothiazole

Product 1

HCID 66760220HCID 66760220, compoundYield 98.2%

Conditions

Temperature
70 °C

Procedure

7-Bromo-2-chlorobenzothiazole (100 mg, 0.40 mmol) was added to dimethylamine (2.0 M in MeOH, 1 mL, 2 mmol) and the solution was heated at 70° C. for 1 h. The crude mixture was purified by ISCO chromatography (100% DCM) to afford 101 mg (98%) of the title compound as white solid. MS (ESI): 257.33, 259.36 [M+H]+; HPLC tR=1.40 min (HPLC: Anayltical—2 min).

Workup

  1. customThe crude mixture was purified by ISCO chromatography (100% DCM)

Sources & evidence

ORD record
ord-5e9a9f2b458341adb89143c9c459d3cf
Source dataset
uspto-grants-2013_02
Patent number
US08378104B2

Reaction notes

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