huagongshe.com
HRID38961

反应详情

EQUATION

反应方程式

HRID 38961 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)CN
HCID79882

2,2-Dimethyl-1-propylamine

C5H13N

结构：Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc(S(C)(=O)=O)cc3O2)cc1
HCID86652935

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)CNC[C@H]1COc2ccc(S(C)(=O)=O)cc2O1
HCID44468378

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

CONDITIONS

反应条件

温度
120 °C

PROCEDURE

实验过程

A mixture of [(2R)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.196 g, 0.5 mmol), 2,2-dimethylpropan-1-amine (1 ml, 8.5 mmol) and ACN (3 ml) was heated under microwave radiation at 120° C. for 20 min. Purification on SCX-3 column (TEA/MeOH) and by flash chromatography (EtOAc) gave the title compound. Yield: 0.1 g. The amine was converted to the hydrochloric acid salt and crystallized from MeOH/Et2O. M.p. 242° C. MS m/z (rel. intensity, 70 eV) 313 (M+, 6), 298 (32), 257 (14), 256 (bp), 207 (12), 100 (92). [α]=−53° (MeOH).

WORKUP

后处理

  1. customPurification on SCX-3 column (TEA/MeOH)