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Diisopropylethylamine → (S)-2-tert-Butoxycarbonylamino-3-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 5-Chlorothiophene-2-carbonyl Chloride | HCID 589223 | — |
| 反応物 | Boc-Dap-OH | HCID 2755946 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (S)-2-tert-Butoxycarbonylamino-3-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid | HCID 67155372 | — |
反応手順
Commercially available (S)-3-Amino-2-tert-butoxycarbonylamino-propionic acid (BOO-Dap-OH) (408 mg, 2 mmol) was suspended in 4 ml DCM and DIPEA (1.75 ml, 10 mmol). 5-Chloro-thiophene-2-carbonyl chloride (362 mg, 2 mmol) (described in WO 2005068456) in 4 ml DCM was added slowly and the mixture was stirred at RT for 2 h. The reaction was filtered and the solvent evaporated. The resulting solid (895 mg) was used without further purification in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08378092B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-a0942b99eb52414894521a8ff2412898 |
| 出典メモ | uspto-grants-2013_02 |