3-Morpholinone → 4-(3-(Benzylthio)-2-chlorophenyl)morpholin-3-one

HRID 389650Notes

Reaction equation

HRID 389650 reaction equation
[CH2:1]([S:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11](Br)[C:10]=1[Cl:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][C:18]1=[O:23]>>[CH2:1]([S:8][C:9]1[C:10]([Cl:16])=[C:11]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][C:18]2=[O:23])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 669533-MorpholinoneHCID 66911177Benzyl(3-bromo-2-chlorophenyl)sulfane

Product 1

HCID 669111644-(3-(Benzylthio)-2-chlorophenyl)morpholin-3-one

Procedure

Intermediate 16 (10 g, 31.38 mmol) was treated with morpholin-3-one (389 mg, 3.85 mmol) according to the procedure described in 1.6).

Sources & evidence

ORD record
ord-df5c4156fcb246f4a75c29ca1b03e785
Source dataset
uspto-grants-2013_02
Patent number
US08378092B2

Reaction notes

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