2-Pyrrolidone → HCID 67155592, compound

HRID 389661Notes

Reaction equation

HRID 389661 reaction equation
[CH2:1]([S:8][C:9]1[CH:14]=[C:13](F)[CH:12]=[C:11](Br)[C:10]=1[Cl:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:18]1[CH2:22][CH2:21][CH2:20][C:19]1=[O:23]>>[CH2:1]([S:8][C:9]1[C:10]([Cl:17])=[C:11]([N:18]2[CH2:22][CH2:21][CH2:20][C:19]2=[O:23])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 67155224HCID 67155224, compound

Product 1

HCID 67155592HCID 67155592, compound

Procedure

Intermediate 35 (35 g, 313.6 mmol) was coupled with pyrrolidin-2-one (11.396 g, 133.91 mmol) in close analogy to the procedure described in step 1.6). After workup the crude product was used without further purification.

Workup

  1. customwas used without further purification

Sources & evidence

ORD record
ord-ab72177fc1544d148cff0d5654e25c44
Source dataset
uspto-grants-2013_02
Patent number
US08378092B2

Reaction notes

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