2-Pyrrolidone → HCID 67155336, compound

HRID 389664Notes

Reaction equation

HRID 389664 reaction equation
[CH2:1]([S:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11](Br)[C:10]=1[CH:16]([F:18])[F:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:19]1[CH2:23][CH2:22][CH2:21][C:20]1=[O:24]>>[CH2:1]([S:8][C:9]1[C:10]([CH:16]([F:18])[F:17])=[C:11]([N:19]2[CH2:23][CH2:22][CH2:21][C:20]2=[O:24])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 67155332HCID 67155332, compound

Product 1

HCID 67155336HCID 67155336, compound

Procedure

Intermediate 55 (2.008 g, 6.1 mmol) was coupled with pyrrolidin-2-one (0.623 g, 7.32 mmol) in close analogy to the procedure described in step 1.6). After workup the crude oil crystallized upon standing overnight and was then triturated with MTBE.

Workup

  1. customcrystallized
  2. customwas then triturated with MTBE

Sources & evidence

ORD record
ord-a0388185f28f4f949748dab9f2ec4031
Source dataset
uspto-grants-2013_02
Patent number
US08378092B2

Reaction notes

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