Diisopropylethylamine → HCID 67155578, compound

Participants

Reaction Steps

Intermediate 82 (170 mg, 0.34 mmol) was dissolved in 10 ml DCM and N-cyclopropyl piperazine (134 mg, 0.38 mmol) was added followed by DIPEA (0.27 ml, 1.54 mmol) and TBTU (121 mg, 0.38 mmol). After 16 h stirring at RT, the solution was evaporated to dryness and purified by silica gel chromatography (Elution with DCM/methanol from 0 to 10% of methanol). The solid obtained after evaporation of the solvents was dissolved in DCM, HCl 2M in Et2O (5 ml) was added and the solvents were evaporated yielding a white powder. Yield: 112 mg, 50% MS (ES+): m/e=604.

Provenance & Evidence