HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → HCID 67155216, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | (S)-2-tert-Butoxycarbonylamino-3-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid | HCID 67155372 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67155216 | HCID 67155216 | — |
Reaction Steps
Intermediate 88 (13.4 g, 38.42 mmol) was dissolved in 200 ml DCM and N-methyl piperazine (8.52 ml, 76.83 mmol) was added followed by DIPEA (26.77 ml, 153.67 mmol) and TBTU (18.5 g, 57.63 mmol). After 16 h stirring at RT, the solution was evaporated to dryness and purified by silica gel chromatography. Yield: 13.05 g, 79%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08378092B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-9893628d8a154532886d17e642c8b049 |
| Source note | uspto-grants-2013_02 |