Benzyl mercaptan → 1-(3-Benzylsulfanyl-2-fluoro-phenyl)-pyrrolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	Benzyl mercaptan	HCID 7509	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)	HCID 636044	—
Reactant	HCID 67155260	HCID 67155260	—
Catalyst	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	1-(3-Benzylsulfanyl-2-fluoro-phenyl)-pyrrolidin-2-one	HCID 67155414	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

Intermediate 98 (1.48 g, 5.73 mmol) in dioxane (50 ml) was stirred under argon. DIPEA (2 ml, 11.47 mmol), xantphos (0.2 g, 0.34 mmol) and Pd2(dba)3 (0.157 g, 0.17 mmol) were added and the reaction was heated to 100° C. Phenyl-methanethiol (0.64 ml, 5.45 mmol) was slowly added and the reaction stirred for 1 h. The reaction was quenched by the addition of 50 ml of H2O. After extraction with ethyl acetate (three times) the combined organic layers were washed with water, dried with Na2SO4, evaporated to dryness and the product was purified by silica gel chromatography.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08378092B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-c2860cbdf4814a9ab7a1f5d279200616
Source note	uspto-grants-2013_02