2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 389696Notes

Reaction equation

HRID 389696 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

Participants

5

Reactant 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

Product 1

HCID 23698872Sodium 2,6-difluorobenzoateYield 100%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-3bb7b79af1a34891b64d1777f159f6db
Source dataset
uspto-grants-2013_02
Patent number
US08378095B2

Reaction notes

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