N-Methylpropylamine → N-Methyl-N-{[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methyl}propan-1-amine

HRID 38971Notes

Reaction equation

HRID 38971 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][C:17]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:18][CH:19]=3)[O:14]2)(=O)=O)=CC=1.[CH3:27][NH:28][CH2:29][CH2:30][CH3:31]>C(#N)C>[CH3:27][N:28]([CH2:12][CH:13]1[CH2:22][CH2:21][C:20]2[C:15](=[CH:16][C:17]([S:23]([CH3:26])(=[O:24])=[O:25])=[CH:18][CH:19]=2)[O:14]1)[CH2:29][CH2:30][CH3:31]

Participants

4

Reactant 2

HCID 12315N-MethylpropylamineHCID 86652940[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 44468511N-Methyl-N-{[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methyl}propan-1-amine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 25: [7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate (0.020 g, 0.0504 mmol), N-methylpropan-1-amine (N—,N—) (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 297 (M+, 2), 131 (5), 87 (6), 86 (bp), 77 (5), 58 (7).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-ccdd700369eb4ee7bd0fec72385339d1
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

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