Sodium Hydroxide → HCID 68572388, compound

HRID 389734Notes

Reaction equation

HRID 389734 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[O:24][C:23]([C:25]4[CH:33]=[CH:32][CH:31]=[C:30]5[C:26]=4[CH:27]=[CH:28][NH:29]5)=[N:22][C:21]=3[C:34]([OH:36])=[O:35])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[O:24][C:23]([C:25]4[CH:26]=[C:30]5[C:31]([CH:27]=[CH:28][NH:29]5)=[CH:32][CH:33]=4)=[N:22][C:21]=3[C:34]([OH:36])=[O:35])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68518086HCID 68518086, compound

Product 1

HCID 68572388HCID 68572388, compound

Procedure

5-(4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)-2-(1H-indol-6-yl)oxazole-4-carboxylic acid was prepared according to the method described for the synthesis of 5-(4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)-2-(1H-indol-4-yl)oxazole-4-carboxylic acid in example M-12, except that during the NaOH mediated hydrolysis the reaction was worked up by acidifying the aqueous phase and extracting the product in DCM.

Workup

  1. customhydrolysis the reaction
  2. extractionextracting the product in DCM

Sources & evidence

ORD record
ord-23a4a2ff047940ff992f240044508308
Source dataset
uspto-grants-2013_02
Patent number
US08378095B2

Reaction notes

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