化工社化工社 化学情報印刷レポート · 研究参考用
Pseudoephedrine → (4S,5S)-2-(5-bromo-2,3-dihydrobenzofuran-7-yl)-3,4-dimethyl-5-phenyl-1,3-oxazolidin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pseudoephedrine | HCID 7028 | — |
| 反応物 | 5-Bromo-2,3-dihydrobenzo[b]furan-7-carbaldehyde | HCID 2794804 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | (4S,5S)-2-(5-bromo-2,3-dihydrobenzofuran-7-yl)-3,4-dimethyl-5-phenyl-1,3-oxazolidin | HCID 67442847 | 79% |
反応手順
A sample of 20 (650 mg, 2.9 mmol) and (1S,2S) pseudoephedrine (500 mg, 3.0 mmol) in 40 mL of benzene was refluxed overnight using a Dean-Stark trap. Solvent removal yielded yellow crystals which were recrystallized from a minimum of hot hexanes to give white crystals of 21 (841 mg, 79%), mp=83.5-85.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383083B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-860afc67fc3a4393b51aabc611d574c0 |
| 出典メモ | uspto-grants-2013_02 |