反应详情

To a solution of 0.20 g of 4-[3-methyl-4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl]-2-trifluoromethylbenzonitrile in 3 mL of pyridine was added 6 mg of dimethylaminopyridine and 0.052 g of succinic anhydride. The mixture is stirred for 12 hours then evaporated to dryness. The crude product is washed with water and extracted with DCM. The organic layer is dried over magnesium sulfate, filtered and evaporated. The crude product is purified by chromatography over silica gel while eluting with 50/50 cyclohexane/ethyl acetate to give the desired compound.

1. customthen evaporated to dryness
2. washThe crude product is washed with water
3. extractionextracted with DCM
4. dry with materialThe organic layer is dried over magnesium sulfate
5. filtrationfiltered
6. customevaporated
7. customThe crude product is purified by chromatography over silica gel
8. washwhile eluting with 50/50 cyclohexane/ethyl acetate