HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-bromo-N-(isoxazol-3-yl)acetamide → (1R/S,3R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-pyrrolidinium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-bromo-N-(isoxazol-3-yl)acetamide | HCID 13362919 | — |
| Reactant | 2-bromo-N-(pyrazin-2-yl)acetamide | HCID 44542669 | — |
| Reactant | (R)-3-hydroxy-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-pyrrolidinium bromide | HCID 87282153 | — |
| Product | (1R/S,3R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-pyrrolidinium bromide | HCID 131730241 | — |
Reaction Steps
This compound is prepared by a method that is analogous to that used to prepare (R)-3-hydroxy-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-pyrrolidinium bromide (Intermediate B) by replacing 2-Bromo-N-pyrazin-2-yl-acetamide (Intermediate A) with 2-Bromo-N-isoxazol-3-yl-acetamide (Intermediate C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383625B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-36af485f94ba4fa0a18b5b8df8a8ac26 |
| Source note | uspto-grants-2013_02 |