HRID389917

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[N@@+]1(CC(=O)Nc2cccnn2)CCC(O)C1.[Br-]

HCID86636495

未命名化合物

2 次

结构：C[N+]1(C(C(N)=O)c2cnccn2)CCCC1OC(=O)C(O)(c1ccccc1)C1CCCCC1.[Br-]

HCID131730243

未命名化合物

结构：C[N+]1(C(C(N)=O)c2cnccn2)CC[C@@H](O)C1.[Br-]

HCID131730247

未命名化合物

PRODUCTS

生成物

结构：C[N+]1(C(C(N)=O)c2cccnn2)CCCC1OC(=O)C(O)(c1ccccc1)C1CCCCC1.[Br-]

HCID131730249

未命名化合物

PROCEDURE

实验过程

This compound is prepared by an analogous method to (1R/S,3R)-3-((R/S)-(2-cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-pyrrolidinium bromide (Example 1) by replacing (1R/S,3R)-3-hydroxy-1-methyl-1-(pyrazin-2-yl-carbamoylmethyl)-pyrrolidinium bromide (Intermediate B) with (R)-3-hydroxy-1-methyl-1-(pyridazin-3-ylcarbamoylmethyl)-pyrrolidinium bromide (Intermediate F).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8aaa8c0d3f5149b2a6c3ab776adc34d1
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08383625B2
来源说明: uspto-grants-2013_02

反应 SMILES

[Br-:1].[CH:2]1([C:8]([OH:34])([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:9]([O:11][CH:12]2[CH2:16][CH2:15][CH2:14][N+:13]2([CH3:27])[CH:17]([C:21]2[CH:26]=NC=C[N:22]=2)[C:18](=[O:20])[NH2:19])=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[Br-].O[C@@H:37]1CC[N+:39](C)(C(C2C=NC=CN=2)C(=O)N)[CH2:38]1.[Br-].OC1CC[N@@+](C)(CC(=O)NC2N=NC=CC=2)C1>>[Br-:1].[CH:2]1([C:8]([OH:34])([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:9]([O:11][CH:12]2[CH2:16][CH2:15][CH2:14][N+:13]2([CH3:27])[CH:17]([C:21]2[N:22]=[N:39][CH:38]=[CH:37][CH:26]=2)[C:18](=[O:20])[NH2:19])=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1