alpha-Cyclopentylmandelic acid → (R/S)-(2-Cyclopentyl-2-hydroxy-2-phenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-methyl-pyrrolidinium bromide

Participants

Role	Name	HCID	Charge
Reactant	alpha-Cyclopentylmandelic acid	HCID 98283	—
Reactant	(R/S)-(2-Cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-methyl-pyrrolidinium bromide	HCID 131730245	—
Product	(R/S)-(2-Cyclopentyl-2-hydroxy-2-phenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-methyl-pyrrolidinium bromide	HCID 131730253	—

Reaction Steps

This compound is prepared by an analogous method to (1R/S,3R)-3((R/S)-(2-cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-1-(isoxazol-3-ylcarbamoylmethyl)-1-methyl-pyrrolidinium bromide (QAX003) (Example 2) by replacing cyclohexyl-hydroxy-phenyl-acetic acid with cyclopentyl-mandelic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08383625B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-b8f6ccb710b44ca5b1258338e033583e
Source note	uspto-grants-2013_02