Morpholine → HCID 56925376, compound

HRID 389932Notes

Reaction equation

HRID 389932 reaction equation
[CH2:1]([NH:3][C:4]([C:6]1[C:10]([NH:11][C:12](=[O:15])[CH:13]=[CH2:14])=[C:9]([C:16]2[CH:21]=[C:20]([Cl:22])[C:19]([O:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:18][C:17]=2[O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[O:8][N:7]=1)=[O:5])[CH3:2].[NH:39]1[CH2:44][CH2:43][O:42][CH2:41][CH2:40]1>CCO>[CH2:1]([NH:3][C:4]([C:6]1[C:10]([NH:11][C:12](=[O:15])[CH2:13][CH2:14][N:39]2[CH2:44][CH2:43][O:42][CH2:41][CH2:40]2)=[C:9]([C:16]2[CH:21]=[C:20]([Cl:22])[C:19]([O:23][CH2:24][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[CH:18][C:17]=2[O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[O:8][N:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 67083242HCID 67083242, compound

Product 1

HCID 56925376HCID 56925376, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-acryloylamino-5-(2,4-bis-benzyloxy-5-chloro-phenyl)-isoxazole-3-carboxylic acid ethylamide as described in example 7 (step viii), (170 mg, 0.32 mmol) and morpholine (1 ml) in EtOH (5 ml) was heated under reflux for 1 h.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1 h.

Sources & evidence

ORD record
ord-b1ff64b4646e4d2c8292b894708d5184
Source dataset
uspto-grants-2013_02
Patent number
US08383616B2

Reaction notes

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