反应详情

To a suspension of EXAMPLE 1A (5 g, 17.1 mmol) in water (40 mL) was added powdered potassium hydroxide (1.92 g, 34.3 mmol), and the mixture was refluxed for 1 hour. After cooling, potassium bisulfate (2 g) was added, and the mixture extracted with ethyl acetate (150 mL). The organics were concentrated on a rotary evaporator and dried under vacuum to yield the title compound. MS (ESI) m/z 230 (M+H)+.

1. temperaturethe mixture was refluxed for 1 hour
2. temperatureAfter cooling
3. extractionthe mixture extracted with ethyl acetate (150 mL)
4. concentrationThe organics were concentrated on a rotary evaporator
5. customdried under vacuum