HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 389974Generated: October 25, 2026
Tetrahydrofuran → [4-(6-Aminopyridin-3-YL)piperazin-1-YL]-(2-trifluoromethylphenyl)methanone
https://huagongshe.com/reaction/389974
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | [4-(6-Nitropyridin-3-yl)piperazin-1-yl]-(2-trifluoromethylphenyl)-methanone | HCID 39235237 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [4-(6-Aminopyridin-3-YL)piperazin-1-YL]-(2-trifluoromethylphenyl)methanone | HCID 67419145 | 49% |
Reaction Steps
To a solution of [4-(6-nitropyridin-3-yl)piperazin-1-yl]-(2-trifluoromethylphenyl)-methanone (0.089 g, 0.23 mmol) in 1:1 THF:MeOH (5 mL) was added 10% Pd/C (0.051 g). The resulting mixture was stirred under hydrogen atmosphere at 25° C. for 4 h. After filtering through a celite cake, the solution was concentrated in vacuo and yielded the title compound as a light yellow solid (0.039 g, 49% yield). MS (ES+) m/z 351.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08383628B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-0486ccf4f3a8436299ae344700d3b835 |
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| Source note | uspto-grants-2013_02 |
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