反应详情

温度

60 °C

2,3-Dioxo-1-p-tolylpiperidine-4-carbonitrile (3.56 g, 15.597 mmol) was added to anhydrous ethanol (52.0 mL) and dissolved by heating to 60° C. After adding hydrazine hydrochloride (1.06 mL, 21.836 mmol) and glacial acetic acid (1.34 mL, 23.396 mmol) room temperature, reaction was carried out for 2 days. After removing ethanol by distillation, the produced solid was filtered and then acetic acid was completely removed by washing with NaHCO3 twice or more times. A target compound (3.25 g, 13.414 mmol, 86.0%) was yielded as white solid.

1. dissolutiondissolved
2. additionAfter adding
3. customAfter removing ethanol
4. distillationby distillation
5. filtrationthe produced solid was filtered
6. customacetic acid was completely removed
7. washby washing with NaHCO3 twice