反应详情

A target compound (925 mg, 3.137 mmol, 62.5%) was yielded as liquid in the same manner as Reference Example 13 by reacting 1-(2,4,5-trimethylphenyl)piperazine (1.03 g, 5.041 mmol) with 3-chloropropionyl chloride (484.9 mg, 5.041 mmol) and purifying by separation through column chromatography (EtOAc/hexane, 1:2).

1. custompurifying by separation through column chromatography (EtOAc/hexane, 1:2)