3-Chloropropionyl chloride → 3-Chloro-1-(4-(2,4,5-trimethylphenyl)piperazin-1-yl)propan-1-one

HRID 390007Notes

Reaction equation

HRID 390007 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][C:3]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[Cl:16][CH2:17][CH2:18][C:19](Cl)=[O:20]>>[Cl:16][CH2:17][CH2:18][C:19]([N:13]1[CH2:12][CH2:11][N:10]([C:3]2[CH:4]=[C:5]([CH3:9])[C:6]([CH3:8])=[CH:7][C:2]=2[CH3:1])[CH2:15][CH2:14]1)=[O:20]

Participants

3

Reactant 2

HCID 693643-Chloropropionyl chlorideHCID 27608211-(2,4,5-Trimethylphenyl)piperazine

Product 1

HCID 679970643-Chloro-1-(4-(2,4,5-trimethylphenyl)piperazin-1-yl)propan-1-one

Procedure

A target compound (925 mg, 3.137 mmol, 62.5%) was yielded as liquid in the same manner as Reference Example 13 by reacting 1-(2,4,5-trimethylphenyl)piperazine (1.03 g, 5.041 mmol) with 3-chloropropionyl chloride (484.9 mg, 5.041 mmol) and purifying by separation through column chromatography (EtOAc/hexane, 1:2).

Workup

  1. custompurifying by separation through column chromatography (EtOAc/hexane, 1:2)

Sources & evidence

ORD record
ord-391c3dc6e6044fa881712465bda8fbba
Source dataset
uspto-grants-2013_02
Patent number
US08383631B2

Reaction notes

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