HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloropropionyl chloride → 3-Chloro-1-(4-(4-cyclohexylphenyl)piperazin-1-yl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloropropionyl chloride | HCID 69364 | — |
| Reactant | 1-(4-Cyclohexylphenyl)piperazine | HCID 2757996 | — |
| Product | 3-Chloro-1-(4-(4-cyclohexylphenyl)piperazin-1-yl)propan-1-one | HCID 67996962 | — |
Reaction Steps
A target compound (2.2 g, 6.569 mmol) was yielded as white solid in the same manner as Reference Example 13 by reacting 1-(4-cyclohexylphenyl)piperazine (2.01 g, 8.224 mmol) with 3-chloropropionyl chloride (0.79 mL, 8.224 mmol) and purifying by separation through column chromatography (EtOAc:hexane:CH2Cl2, 1:1:5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383631B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-138f81b703da42649237545543f1efab |
| Source note | uspto-grants-2013_02 |