Dimethylformamide → HCID 58296315, compound

Participants

Reaction Steps

To a solution of 4-methyl-2-(methylthio)-6-{[4-(methylthio)phenyl]amino}-5-pyrimidinecarboxamide benzamide (0.50 g, 1.57 mmol) in DMF (20 ml) was added dimethylormamide-dimethylacetal (0.56 g, 4.7 mmol), and the reaction mixture was stirred at 85° for 1.5 h. It was cooled to room temperature and DMF was removed under vacuum. The residue was chromatographed (silica gel, eluting with hexane to ethyl acetate gradient followed by 10% methanol in methylene chloride) to yield the product (0.43 g, 72% yield).

Provenance & Evidence