HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-chloro-6-methyl-2-(methylsulfanyl)pyrimidine-5-carboxylate → ethyl 4-({3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]phenyl}amino)-6-methyl-2-(methylthio)-5-pyrimidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-chloro-6-methyl-2-(methylsulfanyl)pyrimidine-5-carboxylate | HCID 22225416 | — |
| Reactant | 2-[2-(3-aminophenyl)ethyl]-1H-isoindole-1,3(2H)-dione | HCID 67219583 | — |
| Product | ethyl 4-({3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]phenyl}amino)-6-methyl-2-(methylthio)-5-pyrimidinecarboxylate | HCID 58296311 | — |
Reaction Steps
The compound was prepared from 2-[2-(3-aminophenyl)ethyl]-1H-isoindole-1,3(2H)-dione and ethyl 4-chloro-6-methyl-2-(methylthio)-5-pyrimidinecarboxylate following a synthetic route similar to that described for intermediate 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383635B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-ae25728930674a4e9ca2f66619d4c85d |
| Source note | uspto-grants-2013_02 |