HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 5-Bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxy]phenyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 5-bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxyphenyl)ethanone | HCID 86652947 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 5-Bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxy]phenyl acetate | HCID 86652946 | — |
Reaction Steps
Preparation according to Preparation 7 using 1-(5-bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxyphenyl)ethanone (19.5 g, 67 mmol), CHCl3 and m-CPBA (77%, 60.5 g, 27 mmol). The mixture was heated at reflux for 24 h. The crude product was further used (Preparation 25). MS m/z (rel. intensity, 70 eV) 306 (M+, 4), 304 (M+, 4) 262 (bp), 69 (69), 57 (99).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524766B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-667f8a43232045bcba8934513a35705c |
| Source note | uspto-grants-2013_09 |