HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → Hydrogen Bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 4-[(E)-2-(dimethylamino)ethenyl]-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarbonitrile | HCID 58296313 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Hydrogen Bromide | HCID 260 | — |
| Product | 5-bromo-N-(3-methylphenyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-4-amine | HCID 58296289 | — |
Reaction Steps
The crude 4-[(E)-2-(dimethylamino)ethenyl]-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarbonitrile (1.47 g) was dissolved into acetic acid (5 mL) and a solution of 33% HBr in glacial acetic acid (10 mL) was added. The reaction mixture was stirred at room temperature for 20 min. The mixture was then concentrated under reduced pressure to give the bromopyridine as a HBr salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383635B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-2af835c18cd84dc0b8916523beb4d467 |
| Source note | uspto-grants-2013_02 |