tert-Butoxy bis(dimethylamino)methane → HCID 58296343, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of intermediate 29 (4.16 g, 10.8 mmol) in DMF (100 mL) was added tert-butoxy-N,N,N′,N′-tetramethylmethanediamine (BBDM, 5.63 g, 32.3 mmol). The mixture was stirred for 16 h at 100° C. After cooling to room temperature, the mixture was poured into ice-water (800 mL), filtered and the solid was washed with water, petroleum and the mixture solvent (petroleum:ethyl acetate=3:1) successively, dried to obtain 4.2 g of product as a yellow solid.

Provenance & Evidence