HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 58296303, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- | HCID 83692 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | HCID 44818005 | HCID 44818005 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58296303 | HCID 58296303 | 58.4% |
Reaction Steps
To a solution of 2-[(3-aminopropyl)amino]-4-[(3-methylphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one (50 mg, 0.114 mmol) in N,N-Dimethylformamide (DMF) (1.5 mL) were added N-{[(1,1-dimethylethyl)oxy]carbonyl}-N-methylglycine (25.9 mg, 0.137 mmol), 1H-1,2,3-benzotriazol-1-ol hydrate (34.9 mg, 0.228 mmol), 4-methylmorpholine (57.7 mg, 0.570 mmol), and N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (28.4 mg, 0.148 mmol), and the reaction mixture was stirred for 2.5 h. It was then concentrated and the residue was subjected to reverse-phase HPLC purification to give 33 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383635B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-f40902b7d82249089a00fea9219d6e95 |
| Source note | uspto-grants-2013_02 |