HCID 66953250, compound → HCID 86651326, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 6.5 (1.16 g, 6.55 mmol) was dissolved in a mixture of iPrOH (32 ml) and 2M aq. KOH (14 ml) and stirred at 80° C. for 4 h. The solvent was evaporated and the residue chromatographed on silica gel (CH2Cl2-MeOH-28% aq. NH4OH, 9:1:0.1) to give (2R,3S)-2-amino-4-(methylthio)butane-1,3-diol (0.932 g, 94%) as a yellow solid.

Provenance & Evidence