2,6-Dichloro-4-iodopyridine → HCID 178521586, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2,6-dichloro-4-iodopyridine (6 g, 21.9 mmol) and trans 4-aminocyclohexanol (5.05 g, 43.8 mmol) in 15 mL of a 1:4 mixture of N,N-dimethylformamide/1,4-dioxane was heated in a Biotage Initiator microwave at 200° C. for 55 min. Ethyl acetate (150 mL) was added and the mixture washed with water (100 mL) and brine (50 mL). The organics were concentrated and the residue purified by flash chromatography on silica gel eluting with 60% ethyl acetate in hexanes to provide the title compound. Yield: 3.8 g (49%). MS (DCI/NH3) m/z 353 (M+H)+.

Provenance & Evidence