Water → HCID 178511613, compound

HRID 390101Notes

Reaction equation

HRID 390101 reaction equation
Cl[C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[C:4]([Cl:9])[N:3]=1.[C@H:10]1([NH2:17])[CH2:15][CH2:14][C@H:13]([NH2:16])[CH2:12][CH2:11]1.O>C(O)C>[Cl:9][C:4]1[N:3]=[C:2]([NH:16][C@H:13]2[CH2:14][CH2:15][C@H:10]([NH2:17])[CH2:11][CH2:12]2)[CH:7]=[C:6]([I:8])[CH:5]=1

Participants

5

Reactant 3

HCID 962WaterHCID 117373932,6-Dichloro-4-iodopyridineHCID 178511674HCID 178511674, compound

Product 1

HCID 178511613HCID 178511613, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of 2,6-dichloro-4-iodopyridine (1 g, 3.65 mmol) and trans-cyclohexane-1,4-diamine (2 g, 18 mmol) in ethanol (2 mL) was heated in a Biotage Initiator microwave reactor at 180° C. for 4 h. After cooling, the mixture was poured into water and the solid collected by filtration and washed with water to give the title compound. Yield: 1.02 g (79%). MS (DCI/NH3) m/z 352 (M+H)+.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-367d4edeaccb45118d32c28bd48479fc
Source dataset
uspto-grants-2013_02
Patent number
US08383624B2

Reaction notes

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