HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-{2-[(2R)-Oxiran-2-ylmethoxy]-5-[(trifluoromethyl)sulfonyl]phenyl}ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Glycidyl tosylate, (R)- | HCID 154187 | — |
| Reactant | 1-{2-Hydroxy-5-[(trifluoromethyl)sulfonyl]phenyl}ethanone | HCID 66878154 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-{2-[(2R)-Oxiran-2-ylmethoxy]-5-[(trifluoromethyl)sulfonyl]phenyl}ethanone | HCID 86652948 | — |
Reaction Steps
Preparation according to Preparation 23 using 1-{2-hydroxy-5-[(trifluoromethyl)sulfonyl]phenyl}ethanone (3.2 g, 11.9 mmol), (R)-glycidyltosylate (3.2 g, 14 mmol), K2CO3 (2.0 g, 14.3 mmol) and DMF (30 ml). Yield 2.2 g. MS m/z (rel. intensity, 70 eV) 324 (M+, 4), 277 (83), 255 (69), 253(67), 199 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524766B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-57961e4a3bc24e0cafecf9a851d6072b |
| Source note | uspto-grants-2013_09 |