Sodium Carbonate → HCID 50899241, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of EXAMPLE 38A (40 mg, 0.073 mmol), phenylboronic acid (11 mg, 0.088 mmol) and dichlorobis(triphenylphosphine)palladium (II) (5 mg, 0.007 mmol) was suspended in a mixture of 7:3:2 DME/H2O/EtOH (3 mL). 0.073 mL of 2 M aqueous Na2CO3 solution was added, and the mixture was heated in a microwave reactor at 150° C. for 20 minutes. Methanol (2 mL) was then added. The slightly yellow solid material was collected by filtration, washed with methanol, water, methanol, and dried to give the title product. Yield: 24 mg (82%). MS (DCI/NH3) m/z 546, 548 (M+H)+, 1H NMR (400 MHz, DMSO-d6): 1.16-1.40 (m, 4H), 1.61-1.67 (m, 1H), 1.73-1.79 (m, 2H), 1.95-2.01 (m, 2H), 3.37-3.41 (m, 2H), 3.57-3.64 (m, 1H), 6.80 (d, J=7.93 Hz, 1H), 7.25 (s, 1H), 7.47 (t, J=7.32 Hz, 1H), 7.55 (t, J=7.48 Hz, 2H), 7.62 (s, 1H), 8.24 (d, J=7.02 Hz, 2H), 8.61 (s, 1H), 8.92 (s, 1H).

Provenance & Evidence