HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → [(2S)-7-(Trifluoromethylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-[(2R)-Oxiran-2-ylmethoxy]-5-[(trifluoromethyl)sulfonyl]phenyl acetate | HCID 86652949 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [(2S)-7-(Trifluoromethylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methanol | HCID 67198869 | — |
Reaction Steps
Preparation according to Preparation 20 using 2-[(2R)-oxiran-2-ylmethoxy]-5-[(trifluoromethyl)sulfonyl]phenyl acetate (1.0 g, 3.7 mmol), dioxane (10 ml) and KOH (10%, 10 ml), the mixture stirred at RT for 1 h. Yield 1.0 g. MS m/z (rel. intensity, 70 eV) 298 (M+, 29), 229 (72), 165 (bp), 107 (67), 79 (33).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524766B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-1acb426b52e149b98ebdc866b3fc5ae3 |
| Source note | uspto-grants-2013_09 |