TFA dichloromethane water → 1-Methyl-cyclopropanesulfonic acid (18-hydroxy-2,15-dioxo-3,14,16-triaza-tricyclo[14.3.0.0*4,6*]nonadec-7-ene-4-carbonyl)-amide

Participants

Reaction Steps

The acetal compound 22a (0.301 g, 0.465 mmol) was deprotected using 2:1:0.1 dichloromethane/trifluoroacetic acid/H2O (6.2 ml) at rt for 4 h, then conc onto silica and flash chromatography using 9:1 ethyl acetate/methanol gave the product as a colorless foam (0.065 g, 30%). LR-MS: Calcd for C21H33N4O6S: 469. Found: 469 [M+H].

Provenance & Evidence