3-(2,3-dichlorophenyl)prop-2-enoic Acid → (+/-)-(E)-2-(7-chloro-1'-(3-(2-chlorophenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

Participants

Reaction Steps

The title compound was prepared employing a procedure analogous to that described in Example 1 using methyl 2-(7-chloro-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetate and 2,3-dichlorocinnamic acid followed by a procedure analogous to that described in Example 2. LC-MS Method 1 tR=1.88, min, m/z=444, 446, 448; 1H NMR (CDCl3) 1.40 (dd, 1H), 1.52 (d, 2H), 1.74 (m, 1H), 2.39 (m, 1H), 2.48 (m, 1H), 2.6-3.2 (4H), 3.30 (m, 1H), 3.62 (m, 1H), 4.11 (d, 1H), 4.80 (d, 1H), 6.92 (d, 1H), 7.05-7.30 (5H), 7.41 (m, 1H), 7.62 (m, 1H), 8.00 (d, 1H).

Provenance & Evidence