3-(2,3-dichlorophenyl)prop-2-enoic Acid → (+/-)-(E)-2-(7-chloro-1'-(3-(2,3-dichlorophenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:15]=1[C:9]1([CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)[CH2:8][CH:7]2[CH2:16][C:17]([O:19]C)=[O:18].[Cl:21][C:22]1[C:32]([Cl:33])=[CH:31][CH:30]=[CH:29][C:23]=1[CH:24]=[CH:25][C:26](O)=[O:27]>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:15]=1[C:9]1([CH2:10][CH2:11][N:12]([C:26](=[O:27])/[CH:25]=[CH:24]/[C:23]3[CH:29]=[CH:30][CH:31]=[C:32]([Cl:33])[C:22]=3[Cl:21])[CH2:13][CH2:14]1)[CH2:8][CH:7]2[CH2:16][C:17]([OH:19])=[O:18]Participants
3
Procedure
The title compound was prepared employing a procedure analogous to that described in Example 1 using methyl 2-(7-chloro-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetate and 2,3-dichlorocinnamic acid followed by a procedure analogous to that described in Example 2. LC-MS Method 1 tR=1.98, min, m/z=480; 1H NMR (CDCl3) 1.52 (d, 2H), 1.71 (m, 2H), 2.40 (m, 1H), 2.49 (m, 1H), 2.65-3.10 (4H), 3.32 (m, 1H), 3.62 (m, 1H), 4.13 (d, 1H), 4.79 d, 1H), 6.88 (d, 1H), 7.05-7.30 (4H), 7.46 (d, 1H), 7.52 (d, 1H), 8.00 (d, 1H).
Sources & evidence
- ORD record
- ord-21c9847910a84417a57f26d63842fec5
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08383629B2
Reaction notes
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