(2e)-3-(2,6-Dichlorophenyl)acrylic acid → (E)-7-chloro-1'-(3-(2,6-dichlorophenyl)acryloyl)-2-methylspiro[isoindoline-1,4'-piperidin]-3-one

Participants

Reaction Steps

The title compound was prepared following a procedure analogous to that described in Example 1 using 7-chloro-2-methylspiro[isoindoline-1,4′-piperidin]-3-one and 2,6-dichlorocinnamic acid. 1H NMR (CDCl3) 1.82 (m, 2H), 2.99 (m, 2H), 3.35 (s, 3H), 3.68 (m, 1H), 3.88 (m, 1H), 4.18 (m, 1H), 4.49 (m, 1H), 7.06 (d, 1H), 7.1-7.6 (5H), 7.76 (2H).

Provenance & Evidence