(2-(trifluoromethyl)phenyl)acetic acid → 2-(7-Chloro-1'(2-(2-(trifluoromethyl)phenyl)acetyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

HRID 390177Notes

Reaction equation

HRID 390177 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=O.[Cl:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:29]=1[C:23]1([CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[CH2:22][CH:21]2[CH2:30][C:31]([O:33]CC)=[O:32]>>[Cl:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:29]=1[C:23]1([CH2:24][CH2:25][N:26]([C:10](=[O:12])[CH2:9][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[C:2]([F:1])([F:14])[F:13])[CH2:27][CH2:28]1)[CH2:22][CH:21]2[CH2:30][C:31]([OH:33])=[O:32]

Participants

3

Reactant 2

HCID 594597(2-(trifluoromethyl)phenyl)acetic acidHCID 67224803Ethyl 2-(7-chloro-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetate

Product 1

HCID 582957792-(7-Chloro-1'(2-(2-(trifluoromethyl)phenyl)acetyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

Procedure

The title compound was prepared following a procedure analogous to that described in Example 1 using 2-(2-(trifluoromethyl)phenyl)acetic acid and ethyl 2-(7-chloro-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetate. LC-MS Method 1 tR=1.83, min, m/z=468, 466

Sources & evidence

ORD record
ord-fedcfaf6e9a14fce8a9de58ac8f01136
Source dataset
uspto-grants-2013_02
Patent number
US08383629B2

Reaction notes

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