2-[2-(Trifluoromethoxy)phenyl]acetic acid → 2-(7-Chloro-1'-(2-(2-(trifluoromethoxy)phenyl)acetyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

HRID 390178Notes

Reaction equation

HRID 390178 reaction equation
[F:1][C:2]([F:15])([F:14])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([OH:13])=O.[Cl:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:30]=1[C:24]1([CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[CH2:23][CH:22]2[CH2:31][C:32]([O:34]CC)=[O:33]>>[Cl:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:30]=1[C:24]1([CH2:25][CH2:26][N:27]([C:11](=[O:13])[CH2:10][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[O:3][C:2]([F:1])([F:15])[F:14])[CH2:28][CH2:29]1)[CH2:23][CH:22]2[CH2:31][C:32]([OH:34])=[O:33]

Participants

3

Reactant 2

HCID 27773132-[2-(Trifluoromethoxy)phenyl]acetic acidHCID 67224803Ethyl 2-(7-chloro-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetate

Product 1

HCID 582957872-(7-Chloro-1'-(2-(2-(trifluoromethoxy)phenyl)acetyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

Procedure

The title compound was prepared following a procedure analogous to that described in Example 1 2-(2-(trifluoromethoxy)phenyl)acetic acid and ethyl 2-(7-chloro-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetate. LC-MS Method 1 tR=1.88, min, m/z=484, 482

Sources & evidence

ORD record
ord-4351034f934a4e19bdfc2c39c5a4b27b
Source dataset
uspto-grants-2013_02
Patent number
US08383629B2

Reaction notes

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