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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 390183Generated: October 27, 2026

2-(Trifluoromethyl)benzenepropanoic acid → tert-butyl 1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)-1H-spiro[isoquinoline-4,4'-piperidine]-2(3H)-carboxylate

https://huagongshe.com/reaction/390183

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Trifluoromethyl)benzenepropanoic acidHCID 15284809—
Reactanttert-Butyl 1H-spiro[isoquinoline-4,4'-piperidine]-2(3H)-carboxylateHCID 49760902—
Producttert-butyl 1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)-1H-spiro[isoquinoline-4,4'-piperidine]-2(3H)-carboxylateHCID 58295813—

Reaction Steps

The title compound was prepared following a procedure analogous to that described in Example 1 using 3-(2-(trifluoromethyl)phenyl)propanoic acid and tert-butyl 1H-spiro[isoquinoline-4,4′-piperidine]-2(3H)-carboxylate. LC-MS Method 1 tR=2.18, min, m/z=503

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08383629B2
Source datasetuspto-grants-2013_02
ORD IDord-76621e55086d403e8c6feefaa4f6c5a1
Source noteuspto-grants-2013_02