2-(Trifluoromethyl)benzenepropanoic acid → HCID 58295706, compound

HRID 390186Notes

Reaction equation

HRID 390186 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11]([OH:13])=O.[NH:16]1[CH2:21][CH2:20][C:19]2([C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[NH:23][C:22]2=[O:30])[CH2:18][CH2:17]1>>[F:14][C:2]([F:1])([F:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11]([N:16]1[CH2:21][CH2:20][C:19]2([C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[NH:23][C:22]2=[O:30])[CH2:18][CH2:17]1)=[O:13]

Participants

3

Reactant 2

HCID 152848092-(Trifluoromethyl)benzenepropanoic acidHCID 18435788Spiro(indole-3,4'-piperidin)-2(1H)-one

Product 1

HCID 58295706HCID 58295706, compound

Procedure

The title compound was prepared following a procedure analogous to that described in Example 31 using 3-(2-(trifluoromethyl)phenyl)propanoic acid and spiro[indoline-3,4′-piperidin]-2-one. LC-MS Method 3 tR=1.157, min, m/z=403; 1H NMR (CDCl3) 1.39 (m, 2H), 1.47 (m, 2H), 1.65 (m, 2H), 1.78 (m, 3H), 2.62 (m, 2H), 3.15 (m, 2H), 3.61 (m, 2H), 3.83 (m, 2H), 4.17 (m, 1H), 6.83 (d, 1H), 6.97 (m, 1H), 7.15 (m, 2H), 7.26 (m, 1H), 7.38 (m, 1H), 7.43 (m, 1H), 7.58 (d, 1H), 7.84 (s, 1H).

Sources & evidence

ORD record
ord-bbab2a9aa2a84ec89db041e9702cdca2
Source dataset
uspto-grants-2013_02
Patent number
US08383629B2

Reaction notes

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