HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophene → 3-(2-Amino-5-benzoyl-benzylamino)-N-cyclohexyl-N-methyl-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophene | HCID 8030 | — |
| Reactant | 3-(5-Benzoyl-2-nitro-benzylamino)-N-cyclohexyl-N-methyl-propionamide | HCID 17756485 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(2-Amino-5-benzoyl-benzylamino)-N-cyclohexyl-N-methyl-propionamide | HCID 58625111 | — |
Reaction Steps
A mixture of 3-(5-benzoyl-2-nitro-benzylamino)-N-cyclohexyl-N-methyl-propionamide (9 g, 0.02 mol), 10% palladium on carbon (2 g), and thiophene solution (2 mL) in MeOH (250 mL) was hydrogenated until 3 equivalents of hydrogen were consumed. The reaction mixture was filtered through Dicalite, and the filtrate was concentrated to yield a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383637B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-6f61c0efea5d46b7bb36b922e988d401 |
| Source note | uspto-grants-2013_02 |