HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → N-{[(2S)-8-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | (2R)-8-Fluoro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl 4-methylbenzenesulfonate | HCID 10759436 | — |
| Solvent | HCID 19892622 | HCID 19892622 | — |
| Product | N-{[(2S)-8-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}ethanamine | HCID 66878480 | — |
Reaction Steps
Preparation according to Example 5 using [(2R)-8-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (4.0 g, 11.8 mmol), ethanamine (5 ml, 70% in water) and ACN (10 ml). Flash column chromatography (Isooctane/EtOAc/MeOH) yielded 2.0 g of the title compound. MS m/z (rel. intensity, 70 eV) 211 (M+, 17), 70 (10), 59 (4), 58 (bp), 56 (4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524766B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-00be75d02b46454f89e3b517a218cc70 |
| Source note | uspto-grants-2013_09 |