反应详情

A solution of 3-(2-amino-5-phenoxy-benzylamino)-N-methyl-N-phenyl-propionamide (diamine) (1.4 g, 0.0037 mol) and cyanogen bromide (0.58 g, 0.0055 mol) in 70 mL of ethanol was refluxed for 3 h. The solvent was evaporated to yield a residue, which was crystallized from EtOAc (100 mL). The resulting precipitate was dissolved in ethanol and stirred for 3 h. The resulting precipitate was collected by filtration, washed with ethanol, and dried to yield the title product, pure 3-(2-amino-6-phenoxy-4H-quinazolin-3-yl)-N-cyclohexyl-N-methyl-propionamide.

1. customThe solvent was evaporated
2. customto yield a residue, which
3. customwas crystallized from EtOAc (100 mL)
4. dissolutionThe resulting precipitate was dissolved in ethanol
5. filtrationThe resulting precipitate was collected by filtration
6. washwashed with ethanol
7. customdried