反应详情

A mixture of cyclohexanecarboxylic acid [2-(2-amino-5-benzoyl-benzylamino)-ethyl]-amide (0.0032 mol) in ethanol (30 mL) was stirred at room temperature. Cyanogen bromine (0.0048 mol) was added. The reaction mixture was stirred and refluxed for 2 hours, then cooled and stirred overnight at room temperature resulting in a precipitate. The precipitate was filtered off, washed with diisopropyl ether and dried to yield the title compound as a residue.

1. stirringThe reaction mixture was stirred
2. temperaturerefluxed for 2 hours
3. temperaturecooled
4. stirringstirred overnight at room temperature
5. customresulting in a precipitate
6. filtrationThe precipitate was filtered off
7. washwashed with diisopropyl ether
8. customdried