反应详情

Cyanogen bromide (0.011 mol) was added to a solution of 3-(2-amino-5-benzoyl-benzylamino)-N-cyclohexyl-N-methyl-propionamide (0.01 mol) in methanol (200 mL), stirred at room temperature. The reaction solution was stirred over a weekend at room temperature, then stirred and refluxed for an additional 5 h. The solvent was evaporated to yield a residue. The residue was crystallized from ethyl acetate (100 mLI). The resulting precipitate was filtered off and dried. The product fraction was recrystallized from 2-propanol (50 mL). The crystals were filtered off and dried to yield the title compound as a residue.

1. stirringThe reaction solution was stirred over a weekend at room temperature
2. stirringstirred
3. temperaturerefluxed for an additional 5 h
4. customThe solvent was evaporated
5. customto yield a residue
6. customThe residue was crystallized from ethyl acetate (100 mLI)
7. filtrationThe resulting precipitate was filtered off
8. customdried
9. customThe product fraction was recrystallized from 2-propanol (50 mL)
10. filtrationThe crystals were filtered off
11. customdried