HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(2-Amino-3-propyl-3,4-dihydro-quinazolin-6-yloxy)-benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(2-Amino-3-propyl-3,4-dihydro-quinazolin-6-yloxy)-benzoic acid | HCID 58625045 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(2-Amino-3-propyl-3,4-dihydro-quinazolin-6-yloxy)-benzoyl chloride | HCID 58625157 | — |
Reaction Steps
A mixture of 3-(2-amino-3-propyl-3,4-dihydro-quinazolin-6-yloxy)-benzoic acid (0.0009 mol) in SOCl2 (2 mL) and DCM (10 mL) was stirred for 2 hours at room temperature and then the solvent was evaporated. The obtained residue was stirred in toluene and the solvent was evaporated again to yield the title compound as a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383637B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-e9d48c01f9df4a669b4592331cb6b0f5 |
| Source note | uspto-grants-2013_02 |